Φαρμακευτικός Κόσμος, Συμπληρώματα Διατροφής

27 Vitamin or mineral Drug Type of interaction Folic acid colestipol Decreased bioavailability of vitamin and mineral preparation possible fosphenytoin, phenytoin Increased seizure frequency and decreased phenytoin concentrations pancreatin, sulfasalazine Decreased absorption of folate pyrimethamine Pharmacodynamic antagonism of the antiparasitic effect triamterene Decreased utilization of dietary folate Vitamin B6 altretamine Adversely affects the response duration of altretamine amiodarone Enhances amiodarone-induced photosensitivity reactions contraceptives (combination), hydralazine, isoniazid, penicillamine May increase vitamin B6 requirements fosphenytoin, phenytoin Reduced phenytoin concentrations levodopa Decreased drug effectiveness Vitamin B12 aminosalicylic acid, cimetidine, omeprazole, ranitidine Reduced cyanocobalamin absorption ascorbic acid Reduced amounts of cyanocobalamin available for serum and body stores chloramphenicol Decreased hematologic response to cyanocobalamin colestipol May decrease the bioavailability of vitamin and mineral preparations contraceptives (combination) Decrease in serum vitamin B12 concentrations Ascorbic acid aluminum carbonate (basic), aluminum hydroxide, aluminum phosphate, dihy- droxyaluminum aminoacetate, dihydroxy- aluminum sodium carbonate, magaldrate Aluminum toxicity (personality changes, seizures, coma) amygdalin Increased metabolism of amygdalin, lead- ing to increased cyamide concetrations cyanocobalamin Reduced amounts of cyanocobalamin available for serum and body stores indinavir Decreased plasma indinavir concetrations Vitamin E anisindione, phenprocoumon Enhanced response to anticoagulants cholestyramine Malabsorption of fat-soluble vitamins, decrease in fat-soluble vitamin absorption colestipol, orlistat Decreased vitamin E effectiveness dicumarol, warfarin Increased risk of bleeding Vitamin K pau d’ arco Reduced vitamin K effectiveness warfarin Decreased anticoagulant effectiveness Calcium alendronate, etidronate, levothyroxine, risedronate, tiludronate Reduced drug absorption